new treatment approaches of pseudomonas aeruginosa infection in cystic fibrosis lung disease

New Treatment Approaches of Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease

Implication for health policy/practice/research/medical education: Some new treatment strategies may improve the health of Cystic Fibrosis patients. Novel pharmaceutical formulations such as microspheres would also be an interesting approach in this area. Copyright © 2013, Iranian Society of Pediatrics; Licensee Safnek Ltd. This is an Open Access article distributed under the terms of the Creat...

Maintenance treatment of chronic pseudomonas aeruginosa infection in cystic fibrosis.

Cystic fibrosis lung environment and Pseudomonas aeruginosa infection

BACKGROUND The airways of patients with cystic fibrosis (CF) are highly complex, subject to various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa is recognized as one of the most important pulmonary pathogens and the predominant cause of morbidity and mortality in CF. A multifarious interplay between the host, pathogens, microbiota, and the environment shapes...

Pseudomonas Aeruginosa Infection in Cystic Fibrosis Patients

Cystic Fibrosis is an autosomal recessive genetic disease where the lung is heavily colonized by biofilm forming Pseudomonas aeruginosabacteria. Biofilm due to its thick wall and presence of extracellular polymeric substances confers bacteria with a much higher resistance against antimicrobial compounds and environmental stress. Research has revealed the presence of extracellular DNA (eDNA) in ...

Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime.

In cystic fibrosis patients with Pseudomonas aeruginosa colonization and increasing pulmonary infection, ceftazidime 150 mg/kg/day was compared with 320 mg/kg/day. Changes in clinical findings, laboratory tests, pulmonary function and chest radiographs were evaluated after 14 days of treatment in hospital. Both treatments were associated with a significant improvement, but the higher dose did n...

Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis.

CONTEXT Although Pseudomonas aeruginosa is the most common virulent respiratory pathogen in cystic fibrosis (CF), the longitudinal development of P aeruginosa infection and its effect on antibody responses and lung disease progression in children with CF remain unclear. OBJECTIVE To prospectively examine the epidemiology of P aeruginosa infection and its impact on CF pulmonary morbidity. DE...